{"id":2948,"date":"2024-06-25T12:06:01","date_gmt":"2024-06-25T12:06:01","guid":{"rendered":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/?page_id=2948"},"modified":"2024-06-26T19:14:04","modified_gmt":"2024-06-26T19:14:04","slug":"pipeline","status":"publish","type":"page","link":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/pipeline\/","title":{"rendered":"Pipeline"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Banner Section&#8221; module_id=&#8221;platform&#8221; module_class=&#8221;innerBanner&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_video_mp4=&#8221;https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-content\/uploads\/2024\/06\/DJI_20240201_103510_678_video.mp4&#8243; height=&#8221;500px&#8221; overflow-x=&#8221;hidden&#8221; overflow-y=&#8221;hidden&#8221; custom_padding=&#8221;199px||199px||true|false&#8221; 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custom_padding_phone=&#8221;||10px||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; border_width_bottom=&#8221;6px&#8221; border_color_bottom=&#8221;#3e92ac&#8221; global_colors_info=&#8221;{}&#8221;]\n<div class=\"tabbed-content\">\n    <nav class=\"tabs\">\n        <ul>\n    \n          <li><a  href=\"javascript:void();\" id=\"KSQ-001EX\" data-index=\"2956\" class=\"active cls_2956\">KSQ-001EX<\/a><\/li>\n    \n          <li><a  href=\"javascript:void();\" id=\"KSQ-004EX\" data-index=\"2958\" class=\" cls_2958\">KSQ-004EX<\/a><\/li>\n    \n          <li><a  href=\"javascript:void();\" id=\"KSQ-4279\" data-index=\"2960\" class=\" cls_2960\">KSQ-4279<\/a><\/li>\n<\/ul>\n<\/nav>\n      <section id=\"section_2956\" class=\"item active section_KSQ-001EX\" data-title=\"KSQ-001EX\">\n        <div class=\"item-content\">\n          <div class=\"rowContainer\">\n            <div class=\"column\">\n              <ul>\r\n \t<li><strong>KSQ-001EX<\/strong>\u00a0is\u00a0an investigational eTIL\u00a0therapy\u00a0manufactured using our ExPRESS\u2122 process\u00a0in which the <strong>SOCS1<\/strong> gene is inactivated by CRISPR\/Cas9 gene editing.<\/li>\r\n \t<li>KSQ\u2019s Immune CRISPRomics<sup>\u00ae<\/sup>\u00a0platform identified <strong>SOCS1<\/strong> as a top target,\u00a0constraining TIL anti-tumor function, engraftment, and persistence.<\/li>\r\n \t<li>The U.S. Food and Drug Administration (FDA) has cleared an Investigational New Drug (IND) application for a Phase 1\/2 clinical study of <strong>KSQ-001EX<\/strong>.<\/li>\r\n<\/ul>            <\/div>\n            <div class=\"column\">\n              <ul>\n<li>Phase 1\/2 clinical trial (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06237881?term=KSQ-001EX&amp;rank=1\" target=\"_blank\" rel=\"noopener\">NCT05240898<\/a>):\n<ul>\n<li>The Phase 1\/2 clinical trial is designed as an open-label, safety lead-in study for people with melanoma, head and neck squamous cell carcinoma (HNSCC), and non-small cell lung cancer (NSCLC).<\/li>\n<li>The primary objective of the Phase 1 portion of the trial is to evaluate the safety and tolerability of <strong>KSQ-001EX<\/strong>. In the safety lead-in portion, a cohort of patients will be initially dosed without IL-2.<\/li>\n<li>The primary objective of Phase 2 is to evaluate antitumor activity in indication-specific cohorts.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n            <\/div>\n          <\/div>\n        <\/div>\n      <\/section>\n      <section id=\"section_2958\" class=\"item  section_KSQ-004EX\" data-title=\"KSQ-004EX\">\n        <div class=\"item-content\">\n          <div class=\"rowContainer\">\n            <div class=\"column\">\n              <ul>\r\n \t<li><strong>KSQ-004EX<\/strong>, a dual-edit eTIL investigational therapy in which both the <strong>Regnase-1<\/strong> and <strong>SOCS1<\/strong> genes are inactivated by CRISPR\/Cas9 gene editing, is also manufactured using our ExPRESS process.<\/li>\r\n \t<li>Using our <em>in vivo<\/em> <strong>CRISPR<\/strong><sup><strong>2<\/strong>TM <\/sup>screening approach, we identified <strong>Regnase-1<\/strong> and <strong>SOCS1<\/strong> as the genome\u2019s top dual-edit combination driving best-in-biology anti-tumor potential.<\/li>\r\n \t<li>We are currently conducting IND-enabling studies to advance <strong>KSQ-004EX<\/strong> into clinical development.<\/li>\r\n<\/ul>            <\/div>\n            <div class=\"column\">\n                          <\/div>\n          <\/div>\n        <\/div>\n      <\/section>\n      <section id=\"section_2960\" class=\"item  section_KSQ-4279\" data-title=\"KSQ-4279\">\n        <div class=\"item-content\">\n          <div class=\"rowContainer\">\n            <div class=\"column\">\n              <ul>\r\n \t<li><strong>KSQ-4279<\/strong>\u00a0is a first-in-class, potent, and selective\u00a0small-molecule inhibitor of USP1, a protein that regulates DNA damage response (DDR).<\/li>\r\n \t<li>In\u00a0July\u00a02023, we entered into a worldwide license and collaboration agreement with Roche for the development and commercialization of <strong>KSQ-4279<\/strong>; under the collaboration, Roche has assumed all development responsibilities for <strong>KSQ-4279<\/strong> (as RO7623066).<\/li>\r\n \t<li><strong>KSQ-4279\/RO7623066<\/strong> is currently being studied in a Phase 1 clinical trial in patients with a variety of advanced solid tumors:<\/li>\r\n<\/ul>            <\/div>\n            <div class=\"column\">\n              <ul>\n<li>Phase 1 clinical trial (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05240898?term=KSQ-4279&amp;rank=1\" target=\"_blank\" rel=\"noopener\">NCT05240898<\/a>):\n<ul>\n<li>Expected enrollment is approximately 140 patients and is a dose-escalation and expansion trial of <strong>KSQ-4279<\/strong> as a monotherapy and in combination with a PARP inhibitor or with chemotherapy.<\/li>\n<li>The study\u2019s primary endpoint is to assess the safety of <strong>KSQ-4279<\/strong> both alone and in combination, determine the maximum tolerated dose, and establish a recommended Phase 2 dose.<\/li>\n<li>Secondary endpoints include characterizing the pharmacokinetics of <strong>KSQ-4279<\/strong> and evaluating its preliminary antitumor activity alone and in combination. 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title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;24px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||10px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2024&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div>\n<p class=\"pub-link\"><strong>KSQ-001EX, an Engineered TIL Therapy, Manufactured from a Clinical-Scale, Feeder-Free Process for the Treatment of Solid Tumor Indications<\/strong><br \/><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2024\/04\/202404-KSQ-001EX-AACR-Poster_Final_1_April_2024-Approved-3-1.png\" target=\"_blank\" rel=\"noopener\">Poster<\/a> presented at AACR, April 2024<span><o:p><\/o:p><\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2023&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div>\n<p class=\"pub-link\"><strong style=\"font-size: 20px;\">KSQ-4279, a first-in-class USP1 inhibitor, shows strong combination activity with multiple PARP inhibitors in BRCA mutant cancers<br \/><\/strong><span style=\"font-size: 20px;\"><\/span><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2023\/05\/AACR-Poster-2023-KSQ-4279-PARPi-combination.png\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 20px;\">Poster<\/a><span style=\"font-size: 20px;\"> presented at AACR, April 2023<\/span><\/p>\n<p class=\"pub-link\"><strong>KSQ-4279-mediated USP1 inhibition induces replication-associated DNA gaps that contribute to cell death<br \/><\/strong><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2023\/05\/AACR-Poster-2023-KSQ-4279-Mechanism-of-Action.png\" target=\"_blank\" rel=\"noopener\">Poster<\/a> presented at AACR, April 2023<span><o:p><\/o:p><\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2022&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div>\n<p class=\"pub-link\"><strong style=\"font-size: 20px;\">ExPRESS\u2122: An accelerated process for the manufacture of KSQ-001, a CRISPR\/Cas9-edited eTIL\u00ae product<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2022\/12\/2022-ExPRESS-SITC-poster-V5.jpg\"><span>Poster<\/span><\/a><span> presented at SITC 2022<o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><o:p> <\/o:p><\/span><\/p>\n<p class=\"pub-link\"><strong>Manufacture of KSQ-001, a CRISPR\/Cas9-engineered TIL (eTIL\u00ae) therapy, for the treatment of Head and Neck Squamous Cell Carcinoma<br \/><\/strong><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2023\/05\/2022-HNSCC-SITC-Poster_Final.png\" target=\"_blank\" rel=\"noopener\">Poster<\/a> presented at SITC 2022<\/p>\n<p class=\"pub-link\"><strong>KSQ-4279, a first-in-class USP1 inhibitor shows strong combination activity in BRCA mutant cancers with intrinsic or acquired resistance to PARP inhibitors<br \/><\/strong><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2023\/05\/EORTC-NIC-AACR-2022-poster-final.png\" target=\"_blank\" rel=\"noopener\">Poster<\/a> presented at EORTC-NIC-AACR, October 2022<\/p>\n<p class=\"pub-link\"><strong>\u201cKSQ-4279: A first-in-class USP1 inhibitor for the treatment of cancers with homologous recombination deficiency\u201d<\/strong><br \/><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2023\/05\/AACR-Presentation-New-Drugs-on-the-Horizon-2022-KSQ-4279.pdf\" target=\"_blank\" rel=\"noopener\">Presentation<\/a>, AACR 2022<span><o:p><\/o:p><\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2021&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div>\n<p class=\"DatesNotes\"><span><strong>KSQ-004: Unbiased pair-wise discovery of SOCS1 and Regnase-1 as the top CRISPR\/Cas9 dual-edit combination enhancing in vivo TIL potency against solid tumors<\/strong><o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2022\/12\/2021-KSQ-004-SITC-poster-Final.jpg\"><span>Poster<\/span><\/a><span> presented at SITC 2021<o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><o:p>\u00a0<\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><strong>Development of KSQ-001, An Engineered TIL (eTIL\u00ae) Therapy For Solid Tumors Through CRISPR\/Cas9-Mediated Inactivation Of SOCS1<\/strong><o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2021\/11\/2021-KSQ-001-SITC-poster-Final.jpg\"><span>Poster<\/span><\/a><span> presented at SITC 2021<\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2020&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div>\n<p class=\"DatesNotes\"><strong>Development of KSQ-4279 as a First-in-Class USP1 Inhibitor for the Treatment of BRCA-Deficient Cancers<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2020\/10\/Poster-184-ENA-2020-SECURE.pdf\"><span>Poster<\/span><\/a><span> presented at ENA 2020<o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2020\/10\/2020-Oct-ENA-ORAL003_Wylie-SECURE.pdf\"><span>Plenary Slide Deck<\/span><\/a><span> presented at ENA 2020<o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><o:p>\u00a0<\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><strong>KSQ-001: A CRISPR\/Cas9-Engineered Tumor Infiltrating Lymphocyte (eTIL\u00ae) Therapy For Solid Tumors<\/strong><o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/news-events\/aacr-poster-presentation-ksq-001-a-crispr-cas9-engineered-tumor-infiltrating-lymphocyte-etil-tm-therapy-for-solid-tumors\/\"><span>Poster<\/span><\/a><span> presented at AACR 2020<o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><o:p>\u00a0<\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><span><strong>Systematic Identification Of Potent Guide RNAs With Minimal Off-Target Activity For The CRISPR\/Cas9 Engineering Of KSQ-001, And Engineered Tumor Infiltrating Lymphocyte (eTIL\u00ae)<\/strong><o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/news-events\/asgct-poster-presentation-systematic-identification-of-potent-guide-rnas-with-minimal-off-target-activity-for-the-crispr-cas9-engineering-of-ksq-001-and-engineered-tumor-infiltrating-lymphocyte\/\"><span>Poster<\/span><\/a><span> presented at ASGCT 2020<\/span><\/p>\n<p class=\"DatesNotes\"><strong>Genome-scale in vivo CRISPR\/Cas9 T cell screen unveils targets enabling rational design of engineered Tumor Infiltrating Lymphocyte (eTIL\u00ae) therapies for solid tumors<br \/><\/strong><a href=\"https:\/\/ksqtx.com\/wp-content\/uploads\/2020\/02\/2020-Emerging-cellular-therapies-Keystone-poster-FINALv4-Sm.jpg\" target=\"_blank\" rel=\"noopener\">Keystone Synopsis<\/a>, Engineering the Genome, February 2020<\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\">\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2019&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div><\/div>\n<div>\n<p class=\"DatesNotes\"><span><strong>An Immune-CRISPRomics platform enabling genome-scale and pair-wise combination in vivo T-cell function screens enables comprehensive identification of novel therapeutic targets<\/strong><o:p><\/o:p><\/span><\/p>\n<\/div>\n<div>\n<p class=\"DatesNotes\"><a href=\"https:\/\/ksqtx.com\/news-events\/sitc-poster-presetnation-an-immune-crispromics-platform-enabling-genome-scale-and-pair-wise-combination-in-vivo-t-cell-function-screens-enables-comprehensive-identification-of-novel-therapeutic-tar\/\"><span>Poster<\/span><\/a><span> presented at SITC 2019<o:p><\/o:p><\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2016&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243;]<\/p>\n<div><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27260157\/\" target=\"_blank\" rel=\"noopener\">CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.<\/a><\/div>\n<div>\n<p class=\"DatesNotes\"><span>Cancer Discov. 2016 August<\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;25px||25px||false|false&#8221; custom_padding_tablet=&#8221;0px|20px|0px|20px|false|false&#8221; custom_padding_phone=&#8221;|20px||20px|false|false&#8221; border_width_bottom=&#8221;2px&#8221; border_color_bottom=&#8221;#F47920&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;2014&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221; title_text_color=&#8221;#F47920&#8243; title_font_size=&#8221;20px&#8221; title_line_height=&#8221;28px&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_text _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;27px&#8221; link_font=&#8221;||||on||||&#8221; link_text_color=&#8221;#FFFFFF&#8221; width=&#8221;90%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|phone&#8221; custom_margin=&#8221;|-14px||||&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|desktop&#8221; link_text_color__hover=&#8221;#F47920&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<div><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4432652\/\" target=\"_blank\" rel=\"noopener noreferrer\">Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.<\/a><\/div>\n<div>\n<p class=\"DatesNotes\"><span>Sci. Data. 2014 September<o:p><\/o:p><\/span><\/p>\n<p class=\"DatesNotes\"><a href=\"http:\/\/www.cell.com\/cell\/pdf\/S0092-8674(14)01178-7.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.<br \/><\/a><span>Cell. 2014 October<\/span><\/p>\n<p class=\"DatesNotes\"><span><a href=\"http:\/\/sabatinilab.wi.mit.edu\/pubs\/2013\/wang_science.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Genetic screens in human cells using the CRISPR-Cas9 system.<\/a><br \/>Science. 2014 January<\/span><span><\/span><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Banner Section&#8221; module_id=&#8221;platform&#8221; module_class=&#8221;innerBanner&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; background_video_mp4=&#8221;https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-content\/uploads\/2024\/06\/DJI_20240201_103510_678_video.mp4&#8243; height=&#8221;500px&#8221; overflow-x=&#8221;hidden&#8221; overflow-y=&#8221;hidden&#8221; custom_padding=&#8221;199px||199px||true|false&#8221; bottom_divider_height=&#8221;500px&#8221; da_popup_slug=&#8221;platform&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; width_tablet=&#8221;100%&#8221; width_phone=&#8221;100%&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;100%&#8221; overflow-x=&#8221;hidden&#8221; overflow-y=&#8221;hidden&#8221; custom_margin=&#8221;|60px||60px|false|true&#8221; custom_margin_tablet=&#8221;|20px||20px|false|true&#8221; custom_margin_phone=&#8221;|20px||20px|false|true&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding_tablet=&#8221;0px||0px||false|false&#8221; custom_padding_phone=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Vertical Line&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;default&#8221; positioning=&#8221;absolute&#8221; width=&#8221;100%&#8221; height=&#8221;100%&#8221; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:divi\/placeholder \/-->","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-2948","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/pages\/2948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/comments?post=2948"}],"version-history":[{"count":24,"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/pages\/2948\/revisions"}],"predecessor-version":[{"id":3161,"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/pages\/2948\/revisions\/3161"}],"wp:attachment":[{"href":"https:\/\/s2.designcostaging.com\/clients\/ksqtherapeutics\/wp-json\/wp\/v2\/media?parent=2948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}