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Unlike other therapies being developed to treat chronic cough, Haduvio takes a broader approach to cough management by acting both centrally and peripherally in the nervous system. Haduvio acts as a kappa agonist and a mu antagonist (KAMA), which are opioid receptors that play a key role in controlling cough hypersensitivity, which is thought to be the link across various chronic cough disorders.<\/p>\n
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Haduvio has a novel approach to controlling cough through its KAMA mechanism. By targeting these receptors along the cough reflex arc, it has the potential to work independent of the initial cough trigger.<\/p>\n
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Due <\/strong><\/em>to its KAMA mechanism, <\/em><\/strong>we believe\u00a0Haduvio\u00a0is well suited to address chronic cough across a variety of conditions.<\/em><\/p>\n For more information on our global clinical development programs,<\/strong> please visit our Pipeline page.<\/em><\/p>\n [\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjMxOTYifX0=@” button_text=”PIPELINE” button_alignment=”left” _builder_version=”4.24.2″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”15px” button_text_color=”#7db2ce” button_border_width=”2px” button_border_color=”#7db2ce” button_border_radius=”0px” button_letter_spacing=”3px” button_font=”Oswald|||on|” button_use_icon=”off” custom_margin=”||30px|” custom_padding=”||” button_border_color_hover=”#c99872″ button_border_radius_hover=”0px” button_letter_spacing_hover=”3px” button_bg_color_hover=”#c99872″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”on” button_border_color__hover=”#7db2ce” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”on” button_border_radius__hover=”0px” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”3px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(125,178,206,0.15)” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”60px|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-content\/uploads\/2025\/01\/01_29_25-KAMA-Mechanism.png” title_text=”01_29_25 KAMA Mechanism” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” disabled_on=”on|on|off” _builder_version=”4.27.4″ background_color=”#FFFFFF” custom_margin=”||||false|false” custom_padding=”|5px||5px|true|true” border_width_all=”6px” border_color_all=”#FFFFFF” box_shadow_style=”preset3″ box_shadow_vertical=”22px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" A Comprehensive Approach to Cough HypersensitivityUnlike other therapies being developed to treat chronic cough, Haduvio takes a broader approach to cough management by acting both centrally and peripherally in the nervous system. Haduvio acts as a kappa agonist and a mu antagonist (KAMA), which are opioid receptors that play a key role in controlling cough […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-210","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/comments?post=210"}],"version-history":[{"count":124,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/210\/revisions"}],"predecessor-version":[{"id":3718,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/210\/revisions\/3718"}],"wp:attachment":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/media?parent=210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}