{"id":3196,"date":"2024-01-05T13:49:52","date_gmt":"2024-01-05T13:49:52","guid":{"rendered":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/?page_id=3196"},"modified":"2025-05-29T18:21:51","modified_gmt":"2025-05-29T18:21:51","slug":"pipeline","status":"publish","type":"page","link":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/pipeline\/","title":{"rendered":"Pipeline"},"content":{"rendered":"

[et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.16″ background_color=”#f2faff” use_background_color_gradient=”on” background_color_gradient_stops=”rgba(0,67,106,0.49) 0%|rgba(0,67,106,0.51) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”rgba(0,67,106,0.49)” background_color_gradient_end=”rgba(0,67,106,0.51)” background_image=”https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-content\/uploads\/2019\/01\/trevi_banner_receptors_alt.jpg” background_position=”top_center” custom_padding=”50px|0px|50px|0px|true|false” custom_padding_tablet=”20px||20px||true|false” custom_padding_phone=”” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row custom_padding_last_edited=”on|phone” _builder_version=”4.16″ custom_padding=”36px|0px|36px|0px|false|false” custom_padding_tablet=”” custom_padding_phone=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” admin_label=”Video Title Section” _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”30px|0px|30px|0px|true|false” custom_padding_tablet=”30px||30px||true|false” custom_padding_phone=”30px||30px||true|false” da_disable_devices=”off|off|off” box_shadow_style=”preset1″ saved_tabs=”all” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row admin_label=”Video Row” _builder_version=”4.16″ custom_padding=”|0|0|0|false|false” custom_width_px=”1365px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”Muli|800|||||||” header_text_color=”#00436A” header_font_size=”35px” header_line_height=”1.3em” header_2_font=”Muli|800|||||||” header_2_text_color=”#00436a” header_2_font_size=”22px” header_2_line_height=”1.2em” custom_margin=”0px||” custom_padding=”0px|0px|3px|||” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

A Chronic Cough Pipeline in a Product: Haduvio\u2122<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_6,1_6,1_6,1_6,1_6,1_6″ use_custom_gutter=”on” gutter_width=”1″ disabled_on=”on|on|off” _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”10px|auto|0px|auto|false|false” custom_padding=”12px||12px||false|false” global_colors_info=”{}”][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” text_letter_spacing=”2px” global_colors_info=”{}”]<\/p>\n

INDICATIONS<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||20px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” global_colors_info=”{}”]<\/p>\n

Preclinical<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||20px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” global_colors_info=”{}”]<\/p>\n

Phase 1<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||20px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” global_colors_info=”{}”]<\/p>\n

Phase 2<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_6″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||20px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” global_colors_info=”{}”]<\/p>\n

Phase 3<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”10px||0px||false|false” border_width_top=”1px” border_color_top=”#EBEAEA” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.24.0″ _module_preset=”default” text_font=”|700|||||||” text_text_color=”#00436A” text_font_size=”20px” custom_margin=”||0px||false|false” custom_padding=”||12px||false|false” global_colors_info=”{}”]<\/p>\n

Haduvio (nalbuphine ER)<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” gutter_width=”1″ disabled_on=”off|off|on” module_class=”four-columns” _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”10px||10px||false|false” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||10px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” text_font_size=”14px” global_colors_info=”{}”]<\/p>\n

Preclinical<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||10px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” text_font_size=”15px” global_colors_info=”{}”]<\/p>\n

Phase 1<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||10px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” text_font_size=”15px” global_colors_info=”{}”]<\/p>\n

Phase 2<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”|||10px|false|false” border_width_left=”1px” border_color_left=”#EBEAEA” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#7DB2CE” text_font_size=”15px” global_colors_info=”{}”]<\/p>\n

Phase 3<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.23.4″ _module_preset=”default” custom_margin=”0px||||false|false” custom_padding=”14px||14px||false|false” border_width_top=”1px” border_color_top=”#EBEAEA” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font_size=”18px” custom_padding_tablet=”” custom_padding_phone=”||12px||false|false” custom_padding_last_edited=”on|phone” text_font_size_tablet=”18px” text_font_size_phone=”16px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Chronic Cough in Idiopathic Pulmonary Fibrosis (IPF)<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_counters _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_counter percent=”70″ bar_background_color=”#00436A” _builder_version=”4.23.4″ _module_preset=”default” percent_text_color=”RGBA(255,255,255,0)” percent_font_size=”46px” global_colors_info=”{}” bar_background_color_default=”#7db2ce” use_percentages=”on”][\/et_pb_counter][\/et_pb_counters][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.23.4″ _module_preset=”default” custom_padding=”14px||14px||false|false” border_width_top=”1px” border_color_top=”#EBEAEA” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font_size=”18px” custom_padding_tablet=”” custom_padding_phone=”||12px||false|false” custom_padding_last_edited=”on|phone” text_font_size_tablet=”18px” text_font_size_phone=”16px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Refractory Chronic Cough (RCC)<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_counters _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_counter percent=”60″ bar_background_color=”#00436A” _builder_version=”4.23.4″ _module_preset=”default” percent_text_color=”RGBA(255,255,255,0)” percent_font_size=”46px” global_colors_info=”{}” bar_background_color_default=”#7db2ce” use_percentages=”on”][\/et_pb_counter][\/et_pb_counters][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.23.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#000000″ header_3_text_color=”#00436A” custom_margin=”||2px|||” custom_padding=”|100px|||false|false” custom_padding_tablet=”|0px|||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Haduvio\u2122 (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which we are currently developing for the treatment of patients with serious chronic cough conditions including patients with idiopathic pulmonary fibrosis (IPF) and patients with refractory chronic cough (RCC).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|off” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#IPF” button_text=”Idiopathic Pulmonary Fibrosis” button_alignment=”right” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00436A” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#RCC” button_text=”Refractory Chronic Cough” button_alignment=”left” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00436A” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_button button_url=”#IPF” button_text=”Idiopathic Pulmonary Fibrosis” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00436A” global_colors_info=”{}”][\/et_pb_button][et_pb_button button_url=”#RCC” button_text=”Refractory Chronic Cough” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00436A” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” disabled_on=”on|off|off” admin_label=”Coffee Menu” _builder_version=”4.24.0″ background_color=”rgba(0,67,106,0.69)” background_image=”https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-content\/uploads\/2022\/10\/Coughing-e1664818903476.png” background_blend=”soft-light” custom_padding=”30px||30px||true|false” custom_padding_tablet=”30px||30px||true|false” custom_padding_phone=”30px||30px||true|false” background_last_edited=”on|phone” background_enable_image_phone=”off” da_disable_devices=”off|off|off” box_shadow_style=”preset6″ global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row column_structure=”3_5,2_5″ disabled_on=”on|on|off” _builder_version=”4.24.1″ custom_padding=”50px|0px|50px|0px|true|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text content_tablet=”<\/p>\n

\u201cYou’re just coughing and coughing and coughing and you get all heated up, lightheaded, feel like you want to pass out because the severity of the cough has taken so much out of you\u201d<\/h2>\n

– Chronic Cough Patient<\/h3>\n

Kum E et al. 2022 doi: 10.1183\/23120541.00667-2021<\/p>\n

” content_phone=”” content_last_edited=”on|desktop” _builder_version=”4.24.1″ text_text_color=”#FFFFFF” text_line_height=”2.6em” header_font=”||||||||” header_text_color=”#7DB2CE” header_2_font=”Muli|800|||||||” header_2_text_color=”#FFFFFF” header_2_line_height=”1.6em” header_3_font=”||||||||” header_3_text_color=”#FFFFFF” custom_margin=”||0px” custom_padding=”||20px” text_font_size_tablet=”” text_font_size_phone=”11px” text_font_size_last_edited=”on|phone” header_2_font_size_tablet=”” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

\u201cYou’re just coughing and coughing and coughing and you get all heated up, lightheaded, feel like you want to pass out because the severity of the cough has taken so much out of you\u201d<\/h2>\n

– Chronic Cough Patient<\/h3>\n

Kum E et al. 2022 doi: 10.1183\/23120541.00667-2021<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|on” _builder_version=”4.24.1″ custom_padding=”50px|0px|50px|0px|true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text content_tablet=”<\/p>\n

\u201cYou’re just coughing and coughing and coughing and you get all heated up, lightheaded, feel like you want to pass out because the severity of the cough has taken so much out of you\u201d<\/h2>\n

– Chronic Cough Patient<\/h3>\n

Kum E et al. 2022 doi: 10.1183\/23120541.00667-2021<\/p>\n

” content_phone=”<\/p>\n

\u201cYou’re just coughing and coughing and coughing and you get all heated up, lightheaded, feel like you want to pass out because the severity of the cough has taken so much out of you\u201d<\/h2>\n

– Chronic Cough Patient<\/h3>\n

Kum E et al. 2022 doi: 10.1183\/23120541.00667-2021<\/p>\n

” content_last_edited=”on|desktop” disabled_on=”off|off|on” _builder_version=”4.24.1″ text_text_color=”#FFFFFF” text_line_height=”2.6em” header_font=”||||||||” header_text_color=”#7DB2CE” header_2_font=”Muli|800|||||||” header_2_text_color=”#FFFFFF” header_2_line_height=”1.6em” header_3_font=”||||||||” header_3_text_color=”#FFFFFF” custom_margin=”||0px” custom_padding=”||20px” text_font_size_tablet=”” text_font_size_phone=”11px” text_font_size_last_edited=”on|phone” header_2_font_size_tablet=”” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

\u201cYou’re just coughing and coughing and coughing and you get all heated up, lightheaded, feel like you want to pass out because the severity of the cough has taken so much out of you\u201d<\/h2>\n

– Chronic Cough Patient<\/h3>\n

Kum E et al. 2022 doi: 10.1183\/23120541.00667-2021<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” admin_label=”Video Title Section” _builder_version=”4.16″ background_color=”#ffffff” width=”100%” custom_margin=”||||false|false” custom_padding=”30px|0px|30px|0px|true|false” custom_padding_tablet=”30px||30px||true|false” custom_padding_phone=”30px||30px||true|false” da_disable_devices=”off|off|off” box_shadow_style=”preset1″ saved_tabs=”all” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row module_id=”IPF” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” custom_margin=”||20px||false|false” custom_padding=”20px|20px|20px|20px|true|true” border_color_all=”#7DB2CE” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”#00436A” header_3_font_size=”30px” header_3_line_height=”1.3em” global_colors_info=”{}”]<\/p>\n

Chronic Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF)<\/strong><\/h3>\n

Chronic cough is highly prevalent among approximately 150,000 IPF patients in the U.S., with up to 85% of IPF patients experiencing chronic cough. The impact of chronic cough is significant and debilitating with IPF patients coughing up to 1,500 times per day and may lead to worsening disease, a higher risk of progression, death, or need for lung transplant. Chronic cough also often leads to a decline in patients’ social, physical, and psychological quality of life. There are no approved therapies for the treatment of chronic cough in IPF and current treatment options provide minimal benefit to patients.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” admin_label=”Coffee Menu” _builder_version=”4.16″ background_color=”#EBEAEA” background_enable_image=”off” background_blend=”soft-light” custom_margin=”||||true|false” custom_padding=”59px||59px||true|false” custom_padding_tablet=”||||true|false” custom_padding_phone=”30px||30px||true|false” da_disable_devices=”off|off|off” box_shadow_style=”preset6″ global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row module_id=”RCC” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” custom_margin=”||||false|false” custom_padding=”20px|20px|20px|20px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”4px” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”#00436A” header_3_font_size=”30px” header_3_line_height=”1.3em” global_colors_info=”{}”]<\/p>\n

Refractory Chronic Cough (RCC)<\/h3>\n

Refractory chronic cough affects approximately 2-3 million adults in the U.S. and is caused by cough reflex hypersensitivity in both the central and peripheral nerves. It is highly disruptive and accompanied by a wide range of complications, ranging from urinary incontinence in females to sleep disruption and social embarrassment that causes significant social and economic burdens for patients and those around them.<\/p>\n

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RCC Cough Frequency<\/h3>\n

[\/et_pb_text][grdi_donut_chart show_card=”off” chart_id=”RCC-Cough-Frequency” chart_bg_color=”#EBEAEA” toolbar=”false” label_show=”false” chart_title=”RCC Cough Frequency” chart_title_fontsize=”0px” chart_title_color=”RGBA(255,255,255,0)” title_alignment=”center” tooltip=”false” data_label=”true” datalabel_fontsize=”14px” legend_position=”right” legend_alignment=”left” lenend_fontsize=”16px” element_count=”2″ category=”Medium to High Frequency,Low Frequency” data_element_name=”73,27″ fill_color1=”#00436A” fill_color2=”#A5B3AB” disabled_on=”on|off|off” _builder_version=”4.27.4″ _module_preset=”default” _unique_id=”43f87b65-5c61-44b5-8d4f-55f65d1e3f9b” background_color=”RGBA(255,255,255,0)” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” chart_bg_color__hover_enabled=”on|hover” chart_bg_color__hover=”#EBEAEA”][\/grdi_donut_chart][grdi_donut_chart show_card=”off” chart_id=”RCC-Cough-Frequency-Mobile” chart_bg_color=”#EBEAEA” toolbar=”false” label_show=”false” chart_title=”RCC Cough Frequency” chart_title_fontsize=”0px” chart_title_color=”RGBA(255,255,255,0)” title_alignment=”center” tooltip=”false” data_label=”true” datalabel_fontsize=”14px” legend_alignment=”left” lenend_fontsize=”16px” element_count=”2″ category=”Medium to High Frequency,Low Frequency” data_element_name=”73,27″ fill_color1=”#00436A” fill_color2=”#A5B3AB” disabled_on=”off|on|on” _builder_version=”4.27.4″ _module_preset=”default” _unique_id=”43f87b65-5c61-44b5-8d4f-55f65d1e3f9b” background_color=”RGBA(255,255,255,0)” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” chart_bg_color__hover_enabled=”on|hover” chart_bg_color__hover=”#EBEAEA”][\/grdi_donut_chart][et_pb_text _builder_version=”4.23.4″ _module_preset=”default” text_font_size=”10px” custom_margin=”-20px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

LifeSci Capital Report Nov 2022, US (N=1000)<\/p>\n

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Cough frequency can vary from patient to patient. 73% of RCC patients report a moderate to high frequency of daily coughs and\u00a03 out of every 4 patients remain uncontrolled leaving a large unmet need.<\/p>\n

The most common causes of RCC are asthma, gastroesophageal reflux disease (GERD), non-asthmatic eosinophilic bronchitis, and upper airway cough syndrome or post-nasal drip. There are no approved therapies for RCC in the U.S.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

A Chronic Cough Pipeline in a Product: Haduvio\u2122INDICATIONSPreclinicalPhase 1Phase 2Phase 3Haduvio (nalbuphine ER)PreclinicalPhase 1Phase 2Phase 3Chronic Cough in Idiopathic Pulmonary Fibrosis (IPF)Refractory Chronic Cough (RCC)Haduvio\u2122 (oral nalbuphine ER) is a centrally and peripherally acting investigational therapy which we are currently developing for the treatment of patients with serious chronic cough conditions including patients with idiopathic […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-3196","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/3196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/comments?post=3196"}],"version-history":[{"count":62,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/3196\/revisions"}],"predecessor-version":[{"id":3895,"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/pages\/3196\/revisions\/3895"}],"wp:attachment":[{"href":"https:\/\/s2.designcostaging.com\/clients\/trevitherapeutics-staging\/wp-json\/wp\/v2\/media?parent=3196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}